From there she went to live with her aristocratic aunt and uncle who encouraged her religious inclination by entrusting her education to the Benedictine nuns.
Her career began under the patronage of Cardinal Marcantonio Barbarigo, who entrusted her with the work of founding schools for young women, especially the poor. With Rose Venerini to train school teachers, she co-founded the Pious Teachers, a group dedicated to the education of girls. The young ladies were taught domestic arts, weaving, embroidering, reading, and Christian doctrine. Fifty-two schools were established during Lucy’s lifetime.